2-苄基吲哚及硫色烯類化合物之合成

Abstract

本論文分為兩部分。 第一部份探討利用銅催化，使2-(2-halophenyl)chroman-3-amine進行分子內胺化反應，建構出多種2-((1H-indol-2-yl)methyl)phenol衍生物。此合成策略可以在溫和的反應條件下，簡單的合成出廣泛的2-benzyl-1H-indole衍生物。 第二部分是利用2,2’-dithiodibenzaldehyde及硝基苯乙烯來合成出多樣的硫色烯衍生物。此合成法具有簡單、有效率且符合綠色化學概念的特色。色烯類化合物具有多樣的生物活性，以及在醫藥上廣泛的應用，引起化學家對色烯類化合物的高度興趣；並嘗試以硫原子取代氧原子，期望可以提高分子的生物活性。

The contents of this thesis divided into two parts summarizing the results based on the experimental works performed during the course of study. The first part of this thesis describes the copper-catalyzed intramolecular amination reaction of 2-(2-halophenyl)chroman-3-amine to construct a variety of 2-((1H-indol-2-yl)methyl)phenol derivatives. This method offers an easy access to a wide variety of 2-benzyl-1H-indole derivatives under mild reaction conditions in high yields. The second part focuses on the synthesis thio-nitrochromene derivatives from β-nitrostyrene and 2,2’-dithiodibenzaldehyde in the presence of organocatalyst. This method is a simple, efficient and environmentally friendly in line with the concept of green chemistry.