Browsing by Author "Wu, Hsiu-Chuan"

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Association of TNF-α gene with spontaneous deep intracerebral hemorrhage in the Taiwan population: a case control study
(2010-06-10) Chen, Yi-Chun; Hu, Fen-Ju; Chen, Phoebe; Wu, Yih-Ru; Wu, Hsiu-Chuan; Chen, Sien-Tsong; Lee-Chen, Guey-Jen; Chen, Chiung-Mei
Abstract Background Genetic factors may play a role in susceptibility to spontaneous deep intracerebral hemorrhage (SDICH). Previous studies have shown that TNF-α gene variation was associated with risks of subarachnoid hemorrhage in multiple ethnicities. The present case-control study tested the hypothesis that genetic variations of the TNF-α gene may affect the risk of Taiwanese SDICH. We examined the association of SDICH risks with four single nucleotide polymorphisms (SNPs) within the TNF-α gene promoter, namely T-1031C, C-863A, C-857T, and G-308A. Methods Genotyping was determined by PCR-based restriction and electrophoresis assay for 260 SDICH patients and 368 controls. Associations were tested by logistic regression or general linear models with adjusting for multiple covariables in each gender group, and then in combined. Multiplicative terms of gender and each of the four SNPs were applied to detect the interaction effects on SDICH risks. To account for the multiple testing, permutation testing of 1,000 replicates was performed for empirical estimates. Results In an additive model, SDICH risks were positively associated with the minor alleles -1031C and -308A in men (OR = 1.9, 95% CI 1.1 to 3.4, p = 0.03 and OR = 2.6, 95% CI 1.3 to 5.3, p = 0.005, respectively) but inversely associated with -863A in females (OR = 0.5, 95% CI 0.2 to 0.9, p = 0.03). There were significant interaction effects between gender and SNP on SDICH risks regarding SNPs T-1031C, C-863A, and G-308A (p = 0.005, 0.005, and 0.007, respectively). Hemorrhage size was inversely associated with -857T in males (p = 0.04). Conclusions In the Taiwan population, the associations of genetic variations in the TNF-α gene promoter with SDICH risks are gender-dependent.
主題統整教學對國小學童創造力、問題解決能力及學業成就的影響之研究
(2007) 吳秀娟; Wu, Hsiu-Chuan
本研究旨在根據Palmer（1991）的課程聯結模式，除知識的統整外，並融入創造思考技巧及問題解決策略編擬一套適合國小中年級的課程教學活動，並經由二十四次的實驗教學後，探討此課程對增進國小學童創造力、問題解決能力及學業成就之成效。本研究主要的研究目的有四：一、探討主題統整教學的實施對國小學童創造力之成效。二、探討主題統整教學的實施對國小學童問題解決能力之成效。三、探討主題統整教學的實施對國小學童學業成就之成效。四、瞭解國小學童對主題統整教學的實施其反應程度如何。本研究採不等組前後測實驗設計，以台北縣某公立國小四年級共64名學生為研究對象，一班為實驗組共33人，一班為控制組共31人；實驗組學生接受為期十二週，每週四節課（每節40分鐘），共計四十八節的實驗課程教學，控制組則未接受任何實驗處理。本研究之主要工具為「威廉斯創造力測驗」、「問題解決測驗」與「學業成就測驗」，所得資料以單因子共變數分析進行假設考驗。根據研究結果，本研究之主要發現如下：一、實驗組在威廉斯創造力測驗之改變情形（一）實驗組在「威廉斯創造力測驗」總分之得分顯著高於控制組。（二）實驗組在「威廉斯創造力」分測驗「流暢力」、「開放性」、「變通力」、「精密力」、「標題」得分之差異顯著優於控制組，而分測驗「獨創力」則未能顯著高於控制組。因此，本主題統整課程能提升國小學童的創造力。二、實驗組在問題解決測驗之改變情形（一）實驗組在「問題解決測驗」總分之得分顯著高於控制組。（二）實驗組在「問題解決能力」分測驗「解釋推論」、「猜測原因」、「逆向原因猜測」、「決定解決方法」得分之差異顯著優於控制組，而分測驗「預防問題」則未能顯著高於控制組。因此，本主題統整課程能提升國小學童的問題解決能力。三、實驗組在學業成就之改變情形（一）實驗組在「學業成就測驗」總分之得分顯著高於控制組。（二）實驗組在「學業成就」分測驗「國語」、「數學」、「社會」得分之差異顯著優於控制組。因此，本主題統整課程能提升國小學童的學業成就。四、在「主題統整教學態度問卷」、「教師教學日誌」、「主題統整教學學生自評表暨回饋單」方面，此課程受到大多數學生的喜愛。研究者根據本研究結果加以討論，並提出未來在實施主題統整教學以及研究上的具體建議。