教師著作
Permanent URI for this collectionhttp://rportal.lib.ntnu.edu.tw/handle/20.500.12235/37077
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Item Polymorphisms of the dopaminergic pathway in relation to memory in a healthy Chinese population(2011-09-17) Yeh, T. K.; Hu, C. Y.; Lin, P. J.; Cho, Y. C.; Chang, C. Y.Dopamine signaling in the striatum, hippocampus, and prefrontal cortex has been established to play a critical role in the regulating memory. This study explored the association between memory and specific single nucleotide polymorphisms (SNPs) in genes involved in the dopaminergic pathway in a sample of healthy individuals. One hundred and thirty four Taiwanese undergraduate volunteers were recruited. WMS Chinese versions were employed to evaluate subjects’ memory. Auditory memory was associated significantly with the DRD3 (dopamine D3 receptor) Ser9Gly polymorphism. Our study suggests the possible involvement of genetic polymorphisms in DRD3 in the regulation of auditory memory. Future replicated studies with larger sample sizes and studies that take different ethnic groups into consideration are encouraged.Item Association of catechol-O-methyltransferase (COMT) polymorphism and cognition, BMI, blood pressure, and uric acid in a Chinese cohort(2010-09-04) Yeh, T. K.; Chang, C. Y.; Hu, C.Y.; Lin, P. J.; Yeh, T. C.The catechol-O-methyltransferase (COMT) is an intracellular methylation enzyme that catalyzes degradation pathway and inactivates the function of catecholamines and estrogens, both of which are of known importance for cardiovascular risk factors such as obesity and hypertension. A single nucleotide polymorphism (SNP), a G to A transition in exon 4 of the COMT gene resulting in a valine to methionine substitution at residue 158, has been found to be associated with differential COMT activity. We hypothesized that this polymorphism might play a possible contribution for diversity physiology due to the COMT widespread over the organs and tissues. Totally, 711 volunteers, aged 16–17 years old, all physically healthy Han Chinese descendants were recruited. Subjects underwent extensive anthropometric, clinical and biochemical assessment. The result reveals that subjects with Met/Met homozygous displayed higher BMI, diastolic pressure, and uric acid significantly. This finding may suggest a possible risk factor of COMT in obesity, hypertension, and hyperuricemia.Item Association of polymorphisms in BDNF, MTHFR, and genes involved in the dopaminergic pathway with memory in a healthy Chinese population(Elsevier, 2012-11-01) Yeh, T. K.; Hu, C. Y.; Yeh, T. C.; Lin, P. J.; Wu, C. H.; Lee, P. L.; Chang, C. Y.The contribution of genetic factors to the memory is widely acknowledged. Research suggests that these factors include genes involved in the dopaminergic pathway, as well as the genes for brain-derived neurotrophic factor (BDNF) and methylenetetrahydrofolate reductase (MTHFR). The activity of the products of these genes is affected by single nucleotide polymorphisms (SNPs) within the genes. This study investigates the association between memory and SNPs in genes involved in the dopaminergic pathway, as well as in the BDNF and MTHFR genes, in a sample of healthy individuals. The sample includes 134 Taiwanese undergraduate volunteers of similar cognitive ability. The Chinese versions of the Wechsler Memory Scale (WMS-III) and Wechsler Adult Intelligence Scale (WAIS-III) were employed. Our findings indicate that the BDNF Met66Val polymorphism and dopamine receptor D3 (DRD3) Ser9Gly polymorphism are associated significantly with long-term auditory memory. Further analysis detects no significant associations in the other polymorphisms and indices. Future replicated studies with larger sample sizes, and studies that consider different ethnic groups, are encouraged.