教師著作
Permanent URI for this collectionhttp://rportal.lib.ntnu.edu.tw/handle/20.500.12235/37073
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Item Filial norms and intergenerational support to aging parents in China and Taiwan(2011-07-01) Lin, Ju-Ping; Chin-Chun YiThis study compared intergenerational relations in China and Taiwan. It has been assumed that cultural homogeneity results in filial norms being the shared dominant family value. However, due to different socio-economic experiences, other situational factors could produce different effects in China and Taiwan. Specifically, geographical distance, parental demands, and children's resources were incorporated in the analysis. We suspected that different situational factors might interact with filial norms in producing varying effects on intergenerational support. Data were taken from the 2006 East Asian Social Survey. Results confirmed that the patriarchal family model of intergenerational support remains strong in both China and Taiwan. The traditional Chinese filial norms significantly accounted for all aspects of intergenerational support examined.Item Intergenerational relations and life satisfaction among older women in Taiwan(2011-06-01) Lin, Ju-Ping; Tse-Fan Chang; Chiu-Hua HuangThis study examined the relationship between intergenerational relations and life satisfaction among older women (aged 55 years and older) in Taiwan. According to intergenerational solidarity theory, intergenerational relations are dictated by various components: living arrangements, intergenerational support exchange, intergenerational affection, and intergenerational norms. Data were obtained from the 2006 Taiwan Social Change Survey (N= 281). The main results show that intergenerational relations have a significant effect on the life satisfaction of older women. Western studies have found that playing the giver's role increases the life satisfaction of older people. However, the present study found that being mainly a recipient of support from adult children is related to a higher level of life satisfaction among older Taiwanese women. This study also underscores the importance of the emotional component in intergenerational relations to the well-being of older people. In Taiwan, stronger emotional bonds with adult children increases older women's life satisfaction.Item In vitro antimicrobial and anti-inflammatory effects of herbs against Propionibacterium acnes.(ELSEVIER, 2010-04-01) Tsung-Hsien Tsai, Tzung-Hsun Tsai, Wen-Huey Wu, Jonathon Te-Peng Tseng and Po-Jung Tsai.,Propionibacterium acnes play an important role in the pathogenesis of acne by inducing certain inflammatory mediators and comedogenesis. The objective of this study was to evaluate the antimicrobial and anti-inflammatory effects of herbal extracts against P. acnes. Among the ten tested herbs, methanolic extracts of rose (Rosa damascene), duzhong (Eucommia ulmoides Oliv.), and yerba mate (Ilex paraguariensis) were found to inhibit the growth of P. acnes with respective minimum inhibitory concentrations of 2, 0.5, and 1 mg/ml. In addition, duzhong and yerba mate extracts reduced the secretion of pro-inflammatory cytokines such as tumour necrosis factor-α, interleukin (IL)-8, and IL-1β by human monocytic THP-1 cells pretreated with heat-killed P. acnes at a concentration of 0.1 mg/ml. Our results suggested that duzhong and yerba mate extracts possess both antimicrobial and anti-inflammatory effects against P. acnes and can possibly be used as therapeutic agents for acne.Item Curcumin-induced mitotic spindle defect and cell cycle arrest in human bladder cancer cells is partly through inhibition of Aurora-A(The American Society for Pharmacology and Experimental Therapeutics, 2011-10-01) Liu, H.-S., Ke, C.-S., Cheng, H.-C., Huang, C.-Y. F., and Su, C.-L.,Curcumin, an active compound in turmeric and curry, has been proven to induce tumor apoptosis and inhibit tumor proliferation, invasion, angiogenesis, and metastasis via modulating numerous targets in various types of cancer cells. Aurora A is a mitosis-related serine-threonine kinase and plays important roles in diverse human cancers. However, the effect of curcumin on Aurora A has not been reported. In this study, Aurora A promoter activity and mRNA expression were inhibited in curcumin-treated human bladder cancer T24 cells, suggesting that Aurora A is regulated at the transcription level. We also found that curcumin preferentially inhibited the growth of T24 cells, which show a higher proliferation rate, invasion activity,and expression level of Aurora A compared with that of human immortalized uroepithelial E7cells. Furthermore, inhibition of phosphorylation of Aurora A and its downstream target histone H3 accompanied by the formation of monopolar spindle, induction of G2 /M phase arrest, and reduction in cell division in response to curcumin were detected in T24 cells. These curcumin-induced phenomena were similar to those using Aurora A small interfering RNA and were attenuated by ectopic expression of Aurora A. Therefore, the antitumor mechanism of curcumin is Aurora A-related, which further supports the application of curcumin in treatments of human cancers.Item Kinase gene expression and subcellular protein expression pattern of protein kinase C isoforms in curcumin-treated human hepatocellular carcinoma Hep 3B cells(Springer US, 2011-05-01) Kao, H.-H., Wu, C.-J., Won, S.-J., Shin, J.-W., Liu, H.-S, and Su, C.-L.,Curcumin, a yellow component of turmeric or curry powder, has been demonstrated to exhibit anti-carcinogenic effects in vitro, in vivo, and in human clinical trials. One of its molecular targets is protein kinase C (PKC) which has been reported to play essential roles in apoptosis, cell proliferation, and carcinogenesis. In this study, PKC mRNA expression was significantly inhibited in curcumin-treated human hepatocellular carcinoma (HCC) Hep 3B cells identified using a kinase cDNA microarray. Furthermore, curcumin decreased total protein expression of all PKCs in a time-related manner by immunoblotting of whole cell lysates, nuclear, membrane, and cytosolic fractions. In cytosolic fraction, the expression of PKC-α was totally inhibited by curcumin. In contrast, the expression levels of PKC-ζ and -μ were dramatically increased. Increases in expression of PKC-δ and PKC-ζ in the membrane and nucleus, and PKC-ι in the membrane were detected. In summary, the changes in expression and distribution of subcellular PKC isoforms in curcumin-treated Hep 3B cells suggest possible PKC-associated anti-tumor mechanisms of curcumin and provide alternative therapies for human HCC.Item Involvement of apoptosis and autophagy in reducing mouse hepatoma ML-1 cells growth in inbred BALB/c mice by bacterial fermented soybeans products(Elsevier, 2011-01-01) Su, C.-L., Chen, F.-N., and Won, S.-J.,Followed by the results of our previousn vitroeport (Food Chem. Toxicol., 2007), the efficacy of the soybean fermentation products containing live bacteria (SCB) was demonstrated using a syngeneic animal model. Murine HBV-related hepatoma ML-1 cells, derived from inbred animals and tumorigenic in BALB/c mice, were implanted subcutaneously to the flank of BALB/c mice on day 0. Three days after implantation, SCB (1.0 or 1.3l/mouse/day) or vehicle (water) was orally administrated daily until day 60. The results indicate that SCB significantly reduced (P�<�0.05) the volumes and weights of tumors during the experimental periods. Examination using TUNEL staining on section of tumors revealed apoptotic phenomenon of nuclear DNA double-strand breaks in the groups of mice received SCB. Immunohistochemistry further revealed an autophagic LC3-II punctate pattern. Of note, SCB induced autophagy in the absence or presence of apoptosis, whereas, apoptosis was observed only in combination with autophagy.n vitrotudy using autophagy inhibitor indicated that the induction of autophagy promoted apoptosis. These data imply that the suppression in tumor volumes and tumor weights by oral administration of SCB was due to the induction of apoptotic and autophagic cell death, which suggests therapeutic potential of SCB on HBV-related HCC.Item 學齡前幼兒的故事結構發展：故事文法之分析(臺灣師範大學教育心理與輔導學系, 2011-01-01) 陳欣希; 張鑑如; 陳秀芬本文依據Stein和Glenn (1979)的故事文法架構，分析三、四、五歲共208名幼兒重述圖畫書時之故事結構元素及類型，並檢視其與年齡的關係。研究者採用CHILDES系統進行語料轉譯、編碼和計分，並作單因子變異數分析。研究發現除了「背景」元素未顯現年齡差異外，「內在計畫」、「結果」和「回應」的使用於五歲組和三歲組之間有顯著差異，而「引發事件」、「內在反應」和「嘗試」元素的表現均爲五歲組優於四歲組和三歲組。故事結構類型則隨年齡成長而趨向有目標的情節式故事結構，且包含比較多的因果關係。然而異於過去之研究，國內幼兒之「縮簡式情節」的比例未隨著年齡增長而減少。本研究結果將可瞭解幼兒故事結構的發展，並提出建議以作爲幼兒教育及未來研究的參考。Item 口語和閱讀關連性研究之文獻回顧與展望(臺灣師範大學教育心理與輔導學系, 2011-11-01) 劉惠美; 張鑑如兒童學習閱讀的過程中，口語能力在此過程中扮演哪一種角色？本文以文獻回顧的方式探討國內自1990年到2008年間關於口語和閱讀能力關連性的研究結果，文獻來源為發表在具審查制度的期刊論文，共有12篇。分析結果顯示國內對此議題的探討大都以組間比較的研究設計說明閱讀困難或低閱讀能力學童的口語能力也同時較一般發展學童明顯低落，且各項口語能力和閱讀能力在國小階段大致呈現中低度左右的相關，但究竟是哪些特定面向的口語能力和哪些特定的閱讀能力成份的關連性最強，又或者這些關連性在不同年齡發展階段的本質為何，則仍無法形成定論。本文並針對口語與閱讀關係之研究提出未來研究的展望與建議。Item 指讀及文字討論之共讀方式對幼兒認字的影響(臺灣師範大學教育心理與輔導學系, 2011-12-01) 陳惠茹; 張鑑如本研究目的在探討成人以指讀及文字討論的共讀方式帶領幼兒閱讀童書對其辨認書中字彙能力的影響。四十八位平均年齡四歲三個月的幼兒，分成三組，在不同的成人閱讀指引方式下，共讀「三隻小兔」童書五次，並測試其辨認書中六個字彙的能力。研究結果顯示（1）在「指讀及文字討論」的共讀方式帶領下，幼兒辨認書中字彙的能力與參與「指讀及命名」、「純粹唸讀」共讀活動的幼兒有顯著差異。（2）在「指讀及文字討論」的共讀方式帶領下，幼兒出現較多自發性對印刷文字的討論，且自發的文字討論次數與其認字能力呈現正相關。文中並對未來相關研究及閱讀教學策略提出討論與建議。Item 親子共讀研究文獻回顧與展望(臺灣師範大學教育心理與輔導學系, 2011-11-01) 張鑑如; 劉惠美親子共讀被視為可促進兒童語文能力發展的一項重要家庭活動，是國內外學者關注的研究議題。本文採文獻回顧方式，以整理國外親子共讀研究文獻為基礎，再回顧國內相關期刊論文共十八篇，並提出未來研究之展望與建議。國內所回顧之論文發表時間為2000年至2011年，主要結果顯示（1）兒童閱讀態度與家長閱讀習慣、教育程度和職業等因素有關（2）親子共讀互動方式多以家長為主導，但有個別差異且因幼兒年齡而不同（3）適切的親子共讀活動可增進兒童語言能力、專注力、情緒理解等能力。未來研究建議增加實驗介入和縱貫期設計之研究，並（1）深入探討不同年齡和背景家庭家長親子共讀信念和方式（2）釐清親子共讀經驗對幼兒語言和閱讀相關能力之影響（3）檢驗國內親子共讀介入方案之成效。