研究發展處

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Author: search.filters.author.王佩蓮Subject: search.filters.subject.合成法

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    2'-去氧-5-氟脲核苷(抗腫瘤藥物)之合成法研討
    (國立臺灣師範大學研究發展處, 1981-06-??) 姜宏哲; 王佩蓮
    The synthetic methods of 2'-deoxy-5-fluorouridine (an antitumor drug) reported in-literature were extensively reviewed and discussed.The most economical synthetic route is the method modifide by Brown(5) 2', 3', 5'-Tri-O-acetyluridine was allowed to react with acetic acid containing fluorine. The reaction mixture was treated with ammonia in methyl alcohol to give 5-fluououridine. which was then deoxygenated to give the 2'-deoxy-5-fluorouridinein the overall yield 71%.