化學系
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國立臺灣師範大學化學系座落於公館校區理學院大樓。本系成立於民國五十一年，最初僅設大學部。之後於民國六十三年、七十八年陸續成立化學研究所碩士班和博士班。本系教育目標旨在培養化學專業人才與中等學校自然及化學專業師資，授課著重理論及應用性。本系所現有師資為專任教授25人，另外尚有與中央研究院合聘教授3位，在分析、有機、無機及物理化學四個學門的基礎上發展跨領域之教學研究合作計畫。此外，本系另有助教13位，職技員工1位，協助處理一般學生實驗及行政事務。學生方面，大學部現實際共322人，碩士班現實際就學研究生共174人，博士班現實際就學共55人。
本系一向秉持著教學與研究並重，近年來為配合許多研究計畫的需求，研究設備亦不斷的更新。本系所的研究計畫大部分來自國科會的經費補助。此外，本系提供研究生獎助學金，研究生可支領助教獎學金（TA）、研究獎學金（RA）和部分的個別教授所提供的博士班學生獎學金（fellowships）。成績優良的大學部學生也可以申請獎學金。
本校圖書館藏書豐富，除了本部圖書館外，分部理學院圖書館西文藏書現有13萬餘冊，西文期刊合訂本有911餘種期刊，將近約3萬冊。此外，西文現期期刊約450種，涵蓋化學、生化、生物科技、材料及其他科學類等領域。目前本系各研究室連接校園網路，將館藏查詢、圖書流通、期刊目錄轉載等功能，納入圖書館資訊系統中，並提供多種光碟資料庫之檢索及線上資料庫如Science Citation Index，Chemical Citation Index，Chemical Abstracts，Beilstein，MDL資料庫與STICNET全國科技資訊網路之查詢。
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Item Photothermal cancer therapy via femtosecond-laser-excited FePt nanoparticles(Elsevier, 2013-01-01) C.-L. Chen; L.-R. Kuo; S.-Y. Lee; Y.-K. Hwu; S.-W. Chou; Chia-Chun Chen; F.-H. Chang; K.-H. Lin; D.-H. Tsai; Y.-Y. ChenFePt nanoparticles (NPs) have recently been revealed to be significant multifunctional materials for the applications of biomedical imaging, drug delivery and magnetic hyperthermia due to their novel magnetic properties. In this study, a newly discovered photothermal effect activated by the near infrared (NIR) femtosecond laser for FePt NPs was demonstrated. The threshold laser energy to destroy cancer cells was found to be comparable to that of gold nanorods (Au NRs) previously reported. Through the thermal lens technique, it was concluded that the temperature of the FePt NPs can be heated up to a couple of hundreds degree C in picoseconds under laser irradiation due to the excellent photothermal transduction efficiency of FePt NPs. This finding boosts FePt NPs versatility in multifunctional targeted cancer therapy.Item Surfactant-Directed Synthesis of Ternary Nanostructures: Nanocubes, Polyhedrons, Octahedrons, and Nanowires of PtNiFe.Their Shape-Dependent Oxygen Reduction Activity.(American Chemical Society, 2012-07-10) S.-W. Chou; J.-J. Shyue; C.-H. Chien; Chia-Chun Chen; Y.-Y. Chen; P.-T. ChouWe report a rational method for preparation of ternary alloy (PtNiFe) nanocrystals with various shapes. PtNiFe nanocubes, polyhedrons, and octahedrons are prepared via fine-tuning the alloy compositions and surfactants, so that the crystal facet–surfactant bindings on the growth seed can be well controlled. Nanowires grow in the cylindrical template built via high concentrations of oleylamine. In the electrocatalysis examination, it appears that the oxygen reduction reaction (ORR) activities of all PtNiFe nanostructures outperform that of commercial Pt catalyst in the electrolyte of HClO4 or H2SO4. In HClO4, the order of ORR activity is as follows: octahedrons ≈ nanowires > polyhedrons > nanocubes. PtNiFe nanostructures enclosed by a (111) plane, such as octahedrons and nanowires, give the highest ORR activities. Conversely, in H2SO4, the ORR activity of PtNiFe nanocubes enclosed by {100} facets is the highest among these nanostructures. The ORR activity increases in the order of nanowires ≈ octahedrons < polyhedrons, establishing a shape dependency in the ORR activity, which is valuable upon performing nanocatalysis in fuel cells.Item In vitro and in vivo Studies of FePt Nanoparticles for Dual Modal CT/MRI Molecular Imaging(American Chemical Society, 2010-09-29) S.-W. Chou; Y.-H. Shau; P.-C. Wu; Y.-S. Yang; D.-B. Shieh; Chia-Chun ChenThe water-solvable FePt nanoparticles of 3, 6, and 12 nm in diameter (3 nm-, 6 nm-, and 12 nm-FePt) were synthesized and applied as a dual modality contrast agent for CT/MRI molecular imaging. These nanoparticles present excellent biocompatibility and hemocompatibility in all test concentrations for the imaging contrast. The biodistribution analysis revealed the highest serum concentration and circulation half-life for 12 nm-FePt, followed by 6 nm-FePt then 3 nm-FePt. Thus, the 3 nm-FePt showed higher brain concentrations. Anti-Her2 antibody conjugated FePt nanoparticles demonstrated molecular expression dependent CT/MRI dual imaging contrast effect in MBT2 cell line and its Her2/neu gene knock out counterpart. Selective contrast enhancement of Her2/neu overexpression cancer lesions in both CT and MRI was found in tumor bearing animal after tail vein injection of the nanoparticles. The 12 nm-FePt outperformed 3 nm-FePt in both imaging modalities. These results indicate the potential of FePt nanoparticles to serve as novel multimodal molecular imaging contrast agents in clinical settings.Item Size-dependent magnetic parameters of fcc FePt nanoparticles: applications to magnetic hyperthermia(IOP Publishing, 2010-04-14) M. S. Seehra; V. Singh; P. Dutta; S. Neeleshwar; Y.-Y. Chen; C.-L. Chen; S.-W. Chou; Chia-Chun ChenFor nominal 3 and 9 nm FePt nanoparticles coated with oleylamine/oleic acid and having a face-centred-cubic (fcc) structure, temperature variations (5–300 K) of magnetization M, ac susceptibility χ' and χ'' for the frequency range fm = 0.1–1000 Hz and electron magnetic resonance (EMR) spectra at 9.28 GHz are reported. X-ray diffraction of the samples shows fcc structure with a lattice constant a = 3.84 Å and TEM characterization yields log-normal distributions of the particle sizes with average D = 3.15(0.16) nm and D = 8.70(0.12) nm for the 3 nm and 9 nm samples, respectively. M versus T data for the zero-field-cooled and field-cooled modes yield a blocking temperature TB = 15 K (85 K) for the 3 nm (9 nm) samples whereas the hysteresis loops at 5 K yield a coercivity Hc = 0 Oe (1.4 kOe). Analysis of the data of TB at different fm determined from the peaks in χ'' in ac susceptibility and the temperature variation of the EMR spectra are used to determine the following parameters of the Vogel–Fulcher relaxation for the 3 nm (9 nm) samples respectively: the attempt frequency fo = 8 × 1010 Hz (2 × 1012 Hz); inter-particle interaction temperature To = 3 K (33 K) and anisotropy Ka = 1.96 × 106 ergs cm−3 (4.3 × 105 ergs cm−3). The use of the above parameters for the calculations of the optimum size for magnetic hyperthermia is analysed and discussed.Item Direct evidence of type II band alignment in nanoscale P3HT/CdSe heterostructures(IOP Publishing, 2011-02-11) C.-H. Wang; C.-W. Chen; Y.-T. Chen; C.-T. Chen; Y.-F.Chen; S.-W. Chou; Chia-Chun ChenDue to inherent advantages of both constituent materials, organic/inorganic hybrid composites have attracted increasing attention. One of the fundamental issues needed to be resolved is their band alignment, which governs most of the electrical and optical properties. Here, we report the investigation of optical transition in poly(3-hexylthiophene) (P3HT)/CdSe nano-composites (NCs). It is found that the relaxation dynamics of photo-carriers in NCs is dominated by charge separation effects. Based on the band bending effect and the quantum confinement energy of electrons in the conduction band of CdSe quantum dots, we provide direct evidence of type II band alignment in P3HT/CdSe NCs. The establishment of a type II transition in NCs is very useful for the future design of efficient optoelectronic devices based on conjugated polymer/semiconductor hybrid systems.