科學教育研究所
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本所於民國75年秋奉教育部核准設立，經當時理學院吳院長京一、與數學系、物理系、化學系、生物系、地球科學系等系主任，以及本校科學教育學者之籌備和規劃，分別於75年成立博士班，於76學年度招收第1屆博士班學生，83年成立碩士班，於84學年度起正式招收第1屆碩士班學生，87年成立教學碩士班，於88學年度招收第1屆教學碩士班學生。
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Item Empirical mode decomposition-based approach for intertrial analysis of olfactory event-related potential features(Springer-Verlag, 2012-12-01) Wu, C. H.; Lee, P. L.; Shu, C. H.; Yang, C. Y.; Lo, M. T.; Chang, C. Y.; Hsieh, J. C.This study presents an empirical mode decomposition (EMD)-based method to study the intertrial variability of olfactory event-related potential (OERP) features. The olfactory stimulus in this study was a mixture of 60 % humidity air and 40 % phenyl ethanol alcohol generated by a computer-controlled olfactometer with a constant flow rate of 8 L/min. A 32-channel whole-head EEG system was utilized to investigate the olfactory responses in 12 healthy subjects. Each EEG epoch was segmented based on the olfactory stimulus onset and subsequently decomposed into a set of intrinsic mode functions (IMFs) by using EMD. Only IMFs that met both frequency and spatial dual criteria were chosen as OERP-related IMFs for reconstructing the noise-suppressed single-trial activity, and those significant trials with N1/P2 amplitudes lower/greater than the mean minus/plus two times the standard deviations of baseline amplitudes were denoted as single-trial OERP for intertrial variability analysis. The present approach enables the capability to study intertrial OERP features, such as the latencies and amplitudes of N1 and P2 peaks, on trial-by-trial basis, which may be helpful to shed light on future olfactory dysfunction studies.Item Association of polymorphisms in BDNF, MTHFR, and genes involved in the dopaminergic pathway with memory in a healthy Chinese population(Elsevier, 2012-11-01) Yeh, T. K.; Hu, C. Y.; Yeh, T. C.; Lin, P. J.; Wu, C. H.; Lee, P. L.; Chang, C. Y.The contribution of genetic factors to the memory is widely acknowledged. Research suggests that these factors include genes involved in the dopaminergic pathway, as well as the genes for brain-derived neurotrophic factor (BDNF) and methylenetetrahydrofolate reductase (MTHFR). The activity of the products of these genes is affected by single nucleotide polymorphisms (SNPs) within the genes. This study investigates the association between memory and SNPs in genes involved in the dopaminergic pathway, as well as in the BDNF and MTHFR genes, in a sample of healthy individuals. The sample includes 134 Taiwanese undergraduate volunteers of similar cognitive ability. The Chinese versions of the Wechsler Memory Scale (WMS-III) and Wechsler Adult Intelligence Scale (WAIS-III) were employed. Our findings indicate that the BDNF Met66Val polymorphism and dopamine receptor D3 (DRD3) Ser9Gly polymorphism are associated significantly with long-term auditory memory. Further analysis detects no significant associations in the other polymorphisms and indices. Future replicated studies with larger sample sizes, and studies that consider different ethnic groups, are encouraged.