雙側杏仁複合體中心核之破壞對大白鼠主動規避學習之影響
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Date
1995-10-??
Authors
王玫芳
吳京一
M.F.Wang,C.Y.Wu
Journal Title
Journal ISSN
Volume Title
Publisher
國立臺灣師範大學生命科學學系
Department of Life Science, NTNU
Department of Life Science, NTNU
Abstract
本實驗以大白鼠為實驗動物，研究雙側杏仁複合體中心核破壞後對雙向主動規避學習( two-way active avoidance learning )之影響。動物共分三組：正常組、假手術組、雙側杏仁體中心核破壞組。實驗在雙向穿梭氣籠內進行，每隻動物每天訓練20次，連續六天，記錄其學習次數。結果顯示：到第六天訓練結束之日，正常組、對照組已達80%的臨界標準，而中心核破壞組僅達33%的成績。由本實驗之結果顯示：杏仁複合體中心核與動物的規避學習有密切關係，它被破壞後會造成主動規避行為的缺矢，此可能因影響到動物的情緒，使之變得較不恐懼，故學習能力降低。另一原因可能為學習與記憶的神經機轉受到影響，而造成學習困難。
In this experiment we studied the effect of bilateral lesion in the central nucleus of the amygdala on active avoidance learning in rats. The subjects were assigned to three groups: nonnal group, sham -operation group and lesion group. Testing were perfonned in a two- way shuttle box. Twenty trials per day were given during a peroid of six succesive days and the correct responses were recorded. The results indicated that at the end of training, the nonnal group and sham operation group reached the 80% criterion. But for the lesion group the percent of correct responses never exceeded 33%. The results indicated that the rats with bilateral lesion of the central nucleus of the amygdala showed deficits in two way active avoidance learning. A fear hypothesis was proposed for this central lesion. Another reason for this deficits was that the nervous mechalllsm concerning the learning and memory was damaged.
In this experiment we studied the effect of bilateral lesion in the central nucleus of the amygdala on active avoidance learning in rats. The subjects were assigned to three groups: nonnal group, sham -operation group and lesion group. Testing were perfonned in a two- way shuttle box. Twenty trials per day were given during a peroid of six succesive days and the correct responses were recorded. The results indicated that at the end of training, the nonnal group and sham operation group reached the 80% criterion. But for the lesion group the percent of correct responses never exceeded 33%. The results indicated that the rats with bilateral lesion of the central nucleus of the amygdala showed deficits in two way active avoidance learning. A fear hypothesis was proposed for this central lesion. Another reason for this deficits was that the nervous mechalllsm concerning the learning and memory was damaged.