利用一價銠金屬催化芳基硼酸對3號位具酯基之香豆素化合物進行不對稱1,4-加成反應
| dc.contributor | 吳學亮 | zh_TW |
| dc.contributor | Wu, Hsyueh-Liang | en_US |
| dc.contributor.author | 林子洋 | zh_TW |
| dc.contributor.author | Lin, Zi-Yang | en_US |
| dc.date.accessioned | 2020-12-14T08:58:31Z | |
| dc.date.available | 2020-08-29 | |
| dc.date.available | 2020-12-14T08:58:31Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | 摘要 本論文敘述利用掌性雙環 [2.2.1] 雙烯配體L5a與一價銠金屬形成之催化劑催化芳基硼酸7與三號位具酯基取代之香豆素化合物24進行不對稱1,4-加成反應。此加成反應產生9−99%產率，鏡像超越值7−99%的加成產物25。此方法可以用於合成抗利尿藥物 (R)–Tolterodine (14) | zh_TW |
| dc.description.abstract | Abstract This thesis describes an asymmetric 1,4-conjugated addition reaction of arylboronic acids 7 to various coumarin-3-carboxylic esters 24 in the presence of 3.0 mol % Rh(Ⅰ)-catalyst consisting of chiral diene ligand L5a, affording adducts 25 in up to 99% yield, d.r > 20:1 and 99% ee. This asymmetric transformation demonstrates its usefulness in the synthesis of an anti-diuretic drug, (R)–Tolterodine (14) | en_US |
| dc.description.sponsorship | 化學系 | zh_TW |
| dc.identifier | G060742039S | |
| dc.identifier.uri | http://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22G060742039S%22.& | |
| dc.identifier.uri | http://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/111147 | |
| dc.language | 中文 | |
| dc.subject | 銠金屬催化 | zh_TW |
| dc.subject | 掌性雙烯配基 | zh_TW |
| dc.subject | 1 | zh_TW |
| dc.subject | 4-加成反應 | zh_TW |
| dc.subject | Rh(Ⅰ)-catalyst | en_US |
| dc.subject | chiral diene ligand | en_US |
| dc.subject | 1 | en_US |
| dc.subject | 4-addition reaction | en_US |
| dc.title | 利用一價銠金屬催化芳基硼酸對3號位具酯基之香豆素化合物進行不對稱1,4-加成反應 | zh_TW |
| dc.title | Enantioselective 1,4-Arylation of Coumarin-3-carboxylic Esters Using Rh(І)/Diene Catalysts | en_US |
Files
Original bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- 060742039s01.pdf
- Size:
- 24.11 MB
- Format:
- Adobe Portable Document Format