β-硝基苯乙烯的自由基反應性探討與2，2-雙取代-1-硝基烯類的一鍋到底合成方法開發
Abstract
第一部份
中文摘要
本研究之目的在使用常見的自由基誘發劑-過氧化苯甲醯基
（benzoyl peroxide），以自由基取代反應（加成-離去）的策略，
將雜環或環烷類官能團有立體選擇性的引入，來合成苯乙烯類衍生
物。使用這個方法，可以在廣泛的受質應用上都有高反應性與高選擇
性。這個使用易取得、且具有一鍋到底反應潛力之起始物的反應，在
所有的例子中，都有著優秀的反式-選擇性並伴隨著中到高等的產
率。在此，將利用製備各式各樣的反式-苯乙烯類衍生物，來說明此
方法的合成價值。
Abstract Stereoselective styryl derivatives have been prepared based on radical substitution (addition-elimination) of heterocycles or cyclohydrocarbons units to (E)- β-nitrostyrenes 1 using a common radical initiator-benzoyl peroxide. High reactivity and selectivity with wide substrate scope were attained by using this easy methodology. The reactions using easily obtained and one-pot potential starting materials gave excellent trans-selectivity with medium to high yields in all cases. Synthetic utility of this approach has been demonstrated by the preparation of various trans-styryl derivatives.
Abstract Stereoselective styryl derivatives have been prepared based on radical substitution (addition-elimination) of heterocycles or cyclohydrocarbons units to (E)- β-nitrostyrenes 1 using a common radical initiator-benzoyl peroxide. High reactivity and selectivity with wide substrate scope were attained by using this easy methodology. The reactions using easily obtained and one-pot potential starting materials gave excellent trans-selectivity with medium to high yields in all cases. Synthetic utility of this approach has been demonstrated by the preparation of various trans-styryl derivatives.